/How long does nicotine stay in the human systems?

How long does nicotine stay in the human systems?

How long does nicotine stay in the human systems?

First of all, you should know what nicotine is.

Nicotine is a chemical substance which contains mainly in cigarettes. It plays an important role of the effect of cigarettes and some other product containing nicotine.

Which effects of nicotine in your system?

There are relaxed agents, reducing stress and anxiety. However, nicotine also has many side effects, and the most negative aspect effect of nicotine is the addiction which is so hard for suffering a person to withdraw. Apparently, the negative effect of this substance appears in the whole system of the body.

In particular, in the circulation system, nicotine can cause the several defects of the heart such as uncontrolled heart rate, arrhythmias, coronary artery disease and the increase of blood clotting on the other site of the bloodstream.

Another affected systems are the central nervous system (a headache, dizziness, sleep disturbance) and the respiratory system (COPD, tuberculosis, bronchospasm).

In the urinary system, nicotine increases the risk of bladder cancer. In the gastrointestinal system, this substance cause dry mouth, dyspepsia, heartburn and bad breath.

Also, it affects muscle, joints (pain and tremor).

How nicotine stay in your body?

When nicotine go in the body throughout the air way (nose) or the mouth (if you chew), it is immediately absorbed into the blood then is transport to all system of the body. By the ability to penetrate the brain – blood fence, nicotine performs its effect in the brain so quickly. Then in the liver, nicotine is converted to cotinine by the liver enzymes, cotinine could exist in the body longer than nicotine. Finally, nicotine or cotinine are delivered to the urinary tract. In here they may be excreted out of the body by urine or reabsorb to blood. The other way of the excreted nicotine in through saliva or sweat.

To withdraw the cigarettes mainly nicotine effectively, you should understand clearly when nicotine and cotinine have entirely gone away or in other words, how long nicotine stays in the body. The duration of the process lasts differently depending on the system and how frequently you use cigarettes and the other products related to tobacco.

Nicotine exists in circulation system

In the circulation system, nicotine continuously presents after your body exposes to cigarette even when you smoke directly or inhale indirectly.

Next, nicotine existing in blood in two ways is the binding to the white blood cell or the free presence in plasma. Based on it, nicotine is eliminated in the blood longer than the other system.

With the person who is the first smoking or exposing nicotine infrequently, the duration may be from 7 to 10 days. It depends on the individual factor.

In another hand, with the daily smoker, the amount of nicotine or cotinine concentration is higher, so the time in order to these substances eliminated longer. It may increase up to 3 or 4 months. Besides, you could test the presence of nicotine by the blood testing.

Nicotine in the urinary system

The second primary system which nicotine existed and excreted in the urinary system. From the bloodstream, nicotine is filtrated in the kidney. At this moment, a part of nicotine in blood is eliminated by urine, and the rest is reabsorbed into the circulation system. This process is repeated until nicotine totally goes away. In general, the present time of nicotine in urine is 3 to 4 days in the occasional smoker. However, if the time you smokes longer, the current duration may reach to 3 months. Because the time which nicotine exists in the bladder is quite long, the smoker is at the high risk of the bladder cancer.

Nicotine in saliva

While you are using nicotine in cigarette or products related to tobacco, a small part of it is retained in saliva. It can cause the bad smell in your mouth. Because there are so many kinds of digestive enzymes in the mouth, nicotine disappears faster. It is taken four days maximally for the process.

Nicotine in hair

The smoke which you consume cigarettes adheres to the hair. After that, nicotine could present in the hair follicle and exist quite long since the last expose. It may take three months and depends on the frequency of the use.

It is clear that there are several factors affecting to the duration of nicotine presence since the last use. One of them is the number of smoking per week. Absolutely, nicotine may take a longer time to remove completely in person smoking daily than the person smoking once or 3 times a week. The other reason is the physical cause. The older adults need longer duration than the younger because of the deficiency of some system. The function of liver also determines how long nicotine stays. The better liver metabolizes and eliminates nicotine; the faster nicotine goes away.

However, the most important factor is your life style. If you try to drink more water, the ability of elimination nicotine through urine and sweat is better. Doing exercises is not a bad idea to decrease the time of nicotine present in your system.

Besides, you should eat more the antioxidant food (the food containing high vitamin A, vitamin C, and vitamin E) such guava, lemon or the sea fish.


  1. https://carekees.com/how-long-does-nicotine-stay-in-your-system/
  2. https://www.ncbi.nlm.nih.gov/pubmed/28735272

Muhamamd Mubeen is Onwer of Strong Article. I quickly figured that I wanted my work to matter. To make a difference in somebody's life. That is why I've devoted myself to helping entrepreneurs market in relevant way, because those deeper connections with prospects and leads will turn into more customers. That added value to your business enables you to go out and create an even bigger impact and the value you've provided your customer enables them to do the same.